Fully Automatic Grid Fitting for Genetic Spot Array Images Containing Guide Spots (bibtex)
by Norbert Braendle, Hilmar Lapp, Horst Bischof
Abstract:
In the domain of biotechnology array-based methods are used to gain rapid access to genetic information based on the signals of the individual array elements (spots). For an automated analysis of the spots it is necessary to fit a grid to the spots in the digital image in order to represent the array distortions that may occur in the course of the experiment. In order to make the grid fitting problem tractable in a certain class of experiments spot arrays contain a sub-grid of guide spots with a known signal characteristic. We present an automatic grid fitting method for spot array images containing guide spots. Our approach uses simple image processing methods and takes into account prior knowledge inherent in the imaging process.
Reference:
Fully Automatic Grid Fitting for Genetic Spot Array Images Containing Guide Spots (Norbert Braendle, Hilmar Lapp, Horst Bischof), Technical report, PRIP, TU Wien, 2000.
Bibtex Entry:
@TechReport{PTR-Braendle00a,
  author =	 "Norbert Braendle and Hilmar Lapp and Horst Bischof",
  institution =	 "PRIP, TU Wien",
  number =	 "PRIP-TR-058",
  title =	 "Fully Automatic Grid Fitting for Genetic Spot Array
                  Images Containing Guide Spots",
  year =	 "2000",
  url =		 "ftp://ftp.prip.tuwien.ac.at/pub/publications/trs/tr58.pdf",
  abstract =	 "In the domain of biotechnology array-based methods
                  are used to gain rapid access to genetic information
                  based on the signals of the individual array
                  elements (spots). For an automated analysis of the
                  spots it is necessary to fit a grid to the spots in
                  the digital image in order to represent the array
                  distortions that may occur in the course of the
                  experiment. In order to make the grid fitting
                  problem tractable in a certain class of experiments
                  spot arrays contain a sub-grid of guide spots with a
                  known signal characteristic. We present an automatic
                  grid fitting method for spot array images containing
                  guide spots. Our approach uses simple image
                  processing methods and takes into account prior
                  knowledge inherent in the imaging process.",
}
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